| Chemical Disposition of Boron in Animals and Humans Robert F. Moseman Radian Corporation, Research Triangle Park, North Carolina Abstract
Elemental boron was isolated in 1808. It typically occurs in nature as borates hydrated with varying amounts of water. Important compounds are boric acid and borax. Boron compounds are also used in the production of metals, enamels, and glasses. In trace amounts, boron is essential for the growth of many plants, and is found in animal and human tissues at low concentrations. Poisoning in humans has been reported as the result of accidental ingestion or use of large amounts in the treatment of burns. Boron as boric acid is fairly rapidly absorbed and excreted from the body via urine. The half-life of boric acid in humans is on the order of 1 day. Boron does not appear to accumulate in soft tissues of animals, but does accumulate in bone. Normal levels of boron in soft tissues, urine, and blood generally range from less than 0.05 ppm to no more than 10 ppm. In poisoning incidents, the amount of boric acid in brain and liver tissue has been reported to be as high as 2000 ppm. Recent studies at the National Institute of Environmental Health Sciences have indicated that boron may contribute to reduced fertility in male rodents fed 9000 ppm of boric acid in feed. Within a few days, boron levels in blood and most soft tissues quickly reached a plateau of about 15 ppm. Boron in bone did not appear to plateau, reaching 47 ppm after 7 days on the diet. Cessation of exposure to dietary boron resulted in a rapid drop in bone boron. The analytical methodology developed and validated for these tissues consisted of microwave digestion of samples in concentrated nitric acid, followed by inductively coupled argon plasma emission spectroscopy analyses. The recovery of added boron from tissue samples was quantitative. The precision and accuracy were typically better than 6% and 12%, respectively. The method detection limit is typically 0.02 to 0.04 ppm of boron, depending on the sample matrix. -- Environ Health Perspect 102 (Suppl 7) :113-117 (1994) . Key words: boron, boric acid, ICAP analysis, tissue levels, distribution of boron
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