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| Mouse Lactoferrin Gene: A Marker
for Estrogen and EGF Christina Teng Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina Abstract
Lactoferrin mRNA in the 21-day-old mouse uterus can be increased several hundred-fold by estrogen. The physiological role of lactoferrin in mouse uterus is unclear ; however, it can be a useful marker for the estrogen action in the uterus. The structural organization and the chromosome location of the lactoferrin gene are similar to members of the transferrin gene family. At the 5´ flanking region of the lactoferrin gene, we have characterized two modules that respond to estrogen and growth factor stimulation. Each module is composed of either overlapping or multiple transcription factor-binding elements. The well-characterized estrogen and growth factor response modules in the mouse lactoferrin gene could serve as the foundation to understand the intricate molecular mechanisms of estrogen action and its relationship to growth factors. -- Environ Health Perspect 103(Suppl 7) :17-20 (1995) Key words: estrogen, EGF, mouse uterus, lactoferrin
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