| Neurobehavioral Aspects of Developmental Toxicity Testing Environ Health Perspect 1Bundesinstitut für Arzneimittel und Medizinprodukte, Berlin, Germany; 2Huntingdon Research Centre, Huntingdon, Cambridgeshire, Great Britain Abstract
Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of animal species and data evaluation. Other problematic areas of study design and conduct, selection of litter representatives for testing, what methods to combine in a testing battery, and statistical treatment of results and their interpretation, will need more research and discussion in the future. -- Environ Health Perspect 104(Suppl 2) :407-412 (1996) Key words: prenatal, postnatal, developmental toxicity, behavioral teratology, regulatory studies, guidelines, detection of effects, drugs
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