Volume 105(Suppl 4) June 1997
Mechanisms and Prevention of Cancers
Table of Contents
Susceptibility to Environmental Hazards
PrefaceBernard D. Goldstein and David Peakall
p. 697Joint Report
12th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals: Susceptibility to Environmental Hazards
J. Carl Barrett, Harri Vainio, David Peakall, and Bernard D. Goldstein
p. 699
Individual Susceptibility to ToxicantsGenetic and Environmental Factors Associated with Variation of Human Xenobiotic Glucuronidation and Sulfation
Exposure and Effect Markers as Indicators of Susceptibility
Brian Burchell and Michael W.H. Coughtrie
p. 739Interaction between Dose and Susceptibility to Environmental Cancer: A Short Review
Eino Hietanen, Kirsti Husgafvel-Pursiainen, and Harri Vainio
p. 749Combinations of Susceptible Genotypes and Individual Responses to Toxicants
Ari Hirvonen
p. 755Genetic Polymorphism of Cytochrome P450 as a Biomarker of Susceptibility to Environmental Toxicity
Jun-Yan Hong and Chung S. Yang
p. 759Acetylation as an Indicator of Risk
Nicholas P. Lang
p. 763Metabolic Activation of Toxins: Tissue-specific Expression and Metabolism in Target Organs
Olavi Pelkonen and Hannu Raunio
p. 767DNA Mismatch Repair Gene Mutations in Human Cancer
Päivi Peltomäki
p. 775Mini- and Microsatellites
Claes Ramel
p. 781The Role of Human Glutathione Transferases and Epoxide Hydrolases in the Metabolism of Xenobiotics
Janeric Seidegård and Gunilla Ekström
p. 791Biomarkers of Human Exposure to Pesticides
Wagida A. Anwar
p. 801Biomarkers of Gene Expression: Growth Factors and Oncoproteins
Paul W. Brandt-Rauf
p. 807Factors Influencing Susceptibility to Metals
Michael Gochfeld
p. 817DNA Adducts and Mutations in Occupational and Environmental Biomonitoring
Kari Hemminki
p. 823Cytogenetic Markers of Susceptibility: Influence of Polymorphic Carcinogen-metabolizing Enzymes
Hannu Norppa
p. 829Ethics in Biomarker Studies
Ethical, Social, and Legal Issues Surrounding Studies of Susceptible Populations and Individuals
Colin L. Soskolne
p. 837Susceptibility in Ecosystems
Methods for and Approaches to Evaluating Susceptibility of Ecological Systems to Hazardous Chemicals
Joanna Burger
p. 843Genetic Susceptibility in Ecosystems:The Challenge for Ecotoxicology
Andrew J. Evenden and Michael H. Depledge
p. 849A New Type of Hazardous Chemical: The Chemosensitizers of Multixenobiotic Resistance
Branko Kurelec
p. 855Mechanisms and Prevention of Environmentally Caused Cancers
Introduction: Mechanisms and Prevention of Environmentally Caused Cancers
Neil F. Johnson
p. 863The Causes and Prevention of Cancer: Gaining Perspective
Bruce N. Ames and Lois S. Gold
p. 865Cigarette Smoke Radicals and the Role of Free Radicals in Chemical Carcinogenicity
William A. Pryor
p. 875Epidemiologic Studies of Ionizing Radiation and Cancer: Past Successes and Future Challenges
Jonathan M. Samet
p. 883Breast Cancer Risk and Environmental Exposures
Mary S. Wolff and Ainsley Weston
p. 891Ethnic Differences in Cancer Incidence: A Marker for Inherited Susceptibility?
Frank D. Gilliland
p. 897Alterations in the K-ras and p53 Genes in Rat Lung Tumors
Steven A. Belinsky, Deborah S. Swafford, Gregory L. Finch, Charles E. Mitchell, Gregory Kelly, Fletcher F. Hahn, Marshall W. Anderson, and Kristen J. Nikula
p. 901DNA Adducts as Exposure Biomarkers and Indicators of Cancer Risk
Miriam C. Poirier
p. 907DNA Damage-inducible Genes as Biomarkers for Exposures to Environmental Agents
Neil F. Johnson, Thomas R. Carpenter, Richard J. Jaramillo, and Teresa A. Liberati
p. 913Polymorphisms of H-ras-1 and p53 in Breast Cancer and Lung Cancer: A Meta-analysis
Ainsley Weston and James H. Godbold
p. 919Epidemiology of Ultraviolet-DNA Repair Capacity and Human Cancer
Lawrence Grossman
p. 927Regulation of Eukaryotic Abasic Endonucleases and Their Role in Genetic Stability
Bruce Demple, Lynn Harrison, David M. Wilson III, Richard A.O. Bennett, Toshimitsu Takagi, and A. Gian Ascione
p. 931Recent Molecular Advances in the Approach to Early Lung Cancer Detection and Intervention
James L. Mulshine, Frank Scott, Jun Zhou, Ingalill Avis, Michele Vos, and Anthony M. Treston
p. 935Native Cellular Fluorescence and Its Application to Cancer Prevention
Stimson P. Schantz, Howard E. Savage, Peter Sacks, and Robert R. Alfano
p. 941Perspectives in Cancer Chemoprevention
Gary D. Stoner, Mark A. Morse, and Gary J. Kelloff
p. 945Approaches to Chemoprevention of Lung Cancer Based on Carcinogens in Tobacco Smoke
Stephen S. Hecht
p. 955Chemoprevention by Inducers of Carcinogen Detoxication Enzymes
Thomas W. Kensler
p. 965Polyphenols As Inhibitors of Carcinogenesis
Chung S. Yang, Mao-Jung Lee, Laishun Chen, and Guang-yu Yang
p. 971Cancer Chemoprevention and Therapy by Monoterpenes
Michael N. Gould
p. 977Chemoprevention of Ultraviolet Radiation-induced Skin Cancer
Ronald D. Ley and Vivienne E. Reeve
p. 981Roles of Retinoids and Their Nuclear Receptors in the Development and Prevention of Upper Aerodigestive Tract Cancers
Reuben Lotan
p. 985Dietary Restrictions and Cancer
Ronald Wilson Hart and Angelo Turturro
p. 989
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