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| Uterotrophic Activity of Bisphenol A in the Immature Rat J. Ashby and H. Tinwell Zeneca Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK Abstract
Bisphenol A (BPA) is active in immature AP rat uterotrophic assays when evaluated using either the oral or the subcutaneous (sc) injection routes of exposure (three daily administrations of 400-800 mg/kg BPA) . Premature vaginal opening was seen for 8 of 14 animals exposed to 600 and 800 mg/kg BPA by sc injection. Vaginal opening was not produced by BPA in the gavage studies. These results are consistent with those of Dodds and Lawson [Nature 137:96 (1936) ] who found that BPA induces persistent vaginal cornification in ovariectomized rats exposed to three twice-daily injections of 85 mg/kg BPA (total daily dose 170 mg/kg) , but they conflict with the reported inactivity of BPA in the immature mouse uterotrophic assay. The uterotrophic activity of diethylstilbestrol in the rat is also established (0.04 mg/kg/day for three days) . Key words: bisphenol A, endocrine, estrogen, uterus. Environ Health Perspect 106:719-720 (1998) . [Online 14 October 1998] http://ehpnet1.niehs.nih.gov/docs/1998/106p719-720ashby/ abstract.html Address correspondence to J. Ashby, Zeneca Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK. Received 19 March 1998 ; accepted 23 June 1998.
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