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Environmental Health Perspectives
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Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. EHP is published by the National Institute of Environmental Health Sciences and its content is free online. Print issues are available by paid subscription.DISCLAIMER
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Environmental Health Perspectives Volume 107, Number 11, November 1999 Open Access
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New Microscope Gives Scientists the Inside Scoop on Living Cells New Microscope Gives Scientists the Inside Scoop on Living Cells

Jennifer Medlin

Abstract


Scientists at Pacific Northwest National Laboratory in Richland, Washington, have developed a unique imaging system capable of focusing on a single living cell within an organism. This new technology will be used in what the multidisciplinary team has termed a "cellular observatory" to study the effect of environmental insults to live cells.

Traditional analytical methods require the destruction or significant modification of live cells to examine chemical changes within them. But the new system combines nuclear magnetic resonance technology with optical microscopy to allow researchers to track changes in both the shape and chemical content of a live cell as they occur, offering scientists fresh insights into the way cells work and enabling them to study cell phenomena such as apoptosis and the effects of multiple simultaneous chemical exposures in greater depth than ever before.


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