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Éric Dewailly,^1,2 Gert Mulvad,³ Henning S. Pedersen,³ Pierre Ayotte,^1,2 Alain Demers,² Jean-Philippe Weber,⁴ and Jens C. Hansen⁵

¹Unité de Recherche en Santé Publique, Centre Hospitalier Universitaire de Québec, Beauport, Québec, Canada
²Département de Médecine Sociale et Préventive, Université Laval, Sainte-Foy, Québec, Canada; ³Primary Health Care Clinic, Nuuk, Greenland
⁴Centre de Toxicologie de Québec, Sainte-Foy, Québec, Canada
⁵Center for Arctic Environmental Medicine, Department of Environmental and Occupational Medicine, Aarhus University, Aarhus, Denmark

Abstract

Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits' large consumption of sea mammal fat ; however, available data are limited to blood lipids, milk fat, and adipose tissue. We report results of organochlorine determination in liver, brain, omental fat, and subcutaneous abdominal fat samples collected from deceased Greenlanders between 1992 and 1994. Eleven chlorinated pesticides and 14 polychlorinated biphenyl congeners were measured in tissue lipid extracts by high-resolution gas chromatography with electron capture detection. Mean concentrations of polychlorinated biphenyls, 2,2´-bis(4-chlorophenyl) -1,1-dichloroethylene, ß-hexachlorocyclohexane, hexachlorobenzene, mirex, trans-nonachlor, and oxychlordane in adipose tissue samples from Greenlanders were 3-34-fold higher than those measured using the same analytical method in samples from Canadians in Quebec City, Quebec. Brain lipids contained lower concentrations of all organochlorines than lipids extracted from other tissues. Organochlorine residue levels in lipid extracts from liver, omental fat, and subcutaneous abdominal fat samples were similar, with the exception of ß-hexachlorocyclohexane, which reached a greater concentration in liver lipids than in lipids from both adipose tissues (4-fold ; p < 0.05) . Comparisons with available international data on adipose tissue levels reveal that the organochlorine body burden in the Inuit population of Greenland is presently among the highest resulting from environmental exposure. Key words: adipose tissue, brain, Greenland, insecticides, Inuit, liver, organochlorines, polychlorinated biphenyls. Environ Health Perspect 107:823-828 (1999) . [Online 7 September 1999]

http://ehpnet1.niehs.nih.gov/docs/1999/107p823-828dewailly/ abstract.html

Address correspondence to P. Ayotte, Unité de Recherche en Santé Publique, Centre Hospitalier Universitaire de Québec, 2400 d'Estimauville, Beauport, Québec, Canada G1E 7G9. Telephone: (418) 666-7000 ext. 245. Fax: (418) 666-2776. E-mail: payotte@cspq.qc.ca

Special thanks to L.A. Ferron and É. Pelletier for conducting organochlorine analyses. Funding for this work was provided by Indian and Northern Affairs Canada (Northern Contaminants Program) .

Received 7 October 1998 ; accepted 17 June 1999.